ID 1.14.13.178 DE Methylxanthine N(1)-demethylase. CA (1) Caffeine + O(2) + NAD(P)H = theobromine + NAD(P)(+) + H(2)O + CA formaldehyde. CA (2) Theophylline + O(2) + NAD(P)H = 3-methylxanthine + NAD(P)(+) + H(2)O CA + formaldehyde. CA (3) Paraxanthine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O CA + formaldehyde. CF Fe cation. CC -!- The enzyme from the bacterium Pseudomonas putida shares an CC NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold CC higher activity with NADH than with NADPH. CC -!- Also demethylates 1-methylxantine with lower efficiency. CC -!- Forms part of the degradation pathway of methylxanthines. DR H9N289, NDMA_PSEPU ; //