ID   1.14.13.178
DE   Methylxanthine N(1)-demethylase.
CA   (1) Caffeine + O(2) + NAD(P)H = theobromine + NAD(P)(+) + H(2)O +
CA   formaldehyde.
CA   (2) Theophylline + O(2) + NAD(P)H = 3-methylxanthine + NAD(P)(+) + H(2)O
CA   + formaldehyde.
CA   (3) Paraxanthine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O
CA   + formaldehyde.
CF   Fe cation.
CC   -!- The enzyme from the bacterium Pseudomonas putida shares an
CC       NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold
CC       higher activity with NADH than with NADPH.
CC   -!- Also demethylates 1-methylxantine with lower efficiency.
CC   -!- Forms part of the degradation pathway of methylxanthines.
DR   H9N289, NDMA_PSEPU ;
//