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ENZYME entry: EC 1.14.13.18

Accepted Name
4-hydroxyphenylacetate 1-monooxygenase.
Alternative Name(s)
4-HPA 1-hydroxylase.
4-hydroxyphenylacetate 1-hydroxylase.
4-hydroxyphenylacetic 1-hydroxylase.
Reaction catalysed
  • 4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)
  • 4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)
Comment(s)
Also acts on 4-hydroxyhydratropate forming 2-methylhomogentisate and on 4-hydroxyphenoxyacetate forming hydroquinone and glycolate.
Cross-references
BRENDA1.14.13.18
EC2PDB1.14.13.18
ExplorEnz1.14.13.18
PRIAM enzyme-specific profiles1.14.13.18
KEGG Ligand Database for Enzyme Nomenclature1.14.13.18
IUBMB Enzyme Nomenclature1.14.13.18
IntEnz1.14.13.18
MEDLINEFind literature relating to 1.14.13.18
MetaCyc1.14.13.18
Rhea expert-curated reactions1.14.13.18

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-