ID   1.14.13.181
DE   13-deoxydaunorubicin hydroxylase.
CA   (1) 13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin +
CA   H2O + NADP(+).
CA   (2) 13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O +
CA   NADP(+).
CC   -!- The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and
CC       Streptomyces peucetius show broad substrate specificity for
CC       structures based on an anthracycline aglycone, but have a strong
CC       preference for 4-methoxy anthracycline intermediates
CC       (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their
CC       4-hydroxy analogs (13-deoxycarminomycin and 13-dihydrocarminomycin),
CC       as well as a preference for substrates hydroxylated at the C-13
CC       rather than the C-14 position.
DR   Q93MI2, DOXA_STRC0 ;  Q9ZAU3, DOXA_STRPE ;  Q59971, DOXA_STRS5 ;
//