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ENZYME entry: EC

Accepted Name
L-evernosamine nitrososynthase.
Reaction catalysed
dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)
  • Isolated from the bacterium Micromonospora carbonacea var. africana.
  • The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin.
  • The reaction was studied using dTDP-beta-L-4-epi-vancosamine (dTDP-4- O-desmethyl-beta-L-evernitrosamine).
PRIAM enzyme-specific profiles1.14.13.187
KEGG Ligand Database for Enzyme Nomenclature1.14.13.187
IUBMB Enzyme Nomenclature1.14.13.187
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.13.187

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-