ID 1.14.13.200 DE tetracenomycin A2 monooxygenase-diooxygenase. CA 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + CA tetracenomycin C. CC -!- Isolated from the bacterium Streptomyces glaucescens. CC -!- The enzyme was also isolated from the bacterium Streptomyces CC olivaceus, where it acts on 8-demethyltetracenomycin A2 CC (tetracenomycin B2) as part of elloramycin biosynthesis. CC -!- The reaction involves a monooxygenase reaction which is followed by a CC dioxygenase reaction giving a gem-diol and an epoxide. CC -!- Water opens the epoxide giving two hydroxy groups. CC -!- The gem-diol eliminates water to give a ketone which is then reduced CC to a hydroxy group. DR Q9L4Y1, ELMG_STROV ; P39888, TCMG_STRGA ; //