ID   1.14.13.211
DE   rifampicin monooxygenase.
AN   RIF-O.
CA   (1) rifampicin + NADPH + O2 = rifampicin para-naphthoquinone carboxamide
CA   + NADP(+) + H2O + H(+).
CA   (2) rifampicin + NADH + O2 = rifampicin para-naphthoquinone carboxamide +
CA   NAD(+) + H2O + H(+).
CC   -!- The enzyme has been found in a variety of environmental bacteria,
CC       notably Rhodococcus, Nocardia, and Streptomyces.
CC   -!- It hydroxylates C-2 of rifampicin leading to the linearization of the
CC       molecule.
DR   Q5YTV5, ROX_NOCFA  ;  P95598, ROX_RHOHA  ;  F2R776, ROX_STRVP  ;
//