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ENZYME entry: EC 1.14.13.223

Accepted Name
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase.
Reaction catalysed
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] + NADH + O(2) <=> 3,5-dihydroxy-4-methyl-anthranilyl-[aryl-carrier protein] + NAD(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin.
  • The enzyme is not active with free 3-hydroxy-4-methylanthranilate.
Cross-references
BRENDA1.14.13.223
EC2PDB1.14.13.223
ExplorEnz1.14.13.223
PRIAM enzyme-specific profiles1.14.13.223
KEGG Ligand Database for Enzyme Nomenclature1.14.13.223
IUBMB Enzyme Nomenclature1.14.13.223
IntEnz1.14.13.223
MEDLINEFind literature relating to 1.14.13.223
MetaCyc1.14.13.223
Rhea expert-curated reactions1.14.13.223
UniProtKB/Swiss-Prot
C0LTM1, SIBG_STRSJ

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