ID   1.14.13.231
DE   Tetracycline 11a-monooxygenase.
CA   Tetracycline + NADPH + O(2) = 11a-hydroxytetracycline + NADP(+) + H(2)O.
CF   FAD.
CC   -!- This bacterial enzyme confers resistance to all clinically relevant
CC       tetracyclines when expressed under aerobic conditions.
CC   -!- The hydroxylated products are very unstable and lead to
CC       intramolecular cyclization and non-enzymic breakdown to undefined
CC       products.
DR   Q01911, TETX_BACFG ;  Q93L51, TETX_BACT4 ;  B1MM05, TETX_MYCA9 ;
DR   Q06DK7, TETX_SPHSM ;
//