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ENZYME entry: EC 1.14.13.25

Accepted Name
Methane monooxygenase (soluble).
Alternative Name(s)
Methane hydroxylase.
Reaction catalysed
Methane + NAD(P)H + O(2) <=> methanol + NAD(P)(+) + H(2)O
Comment(s)
  • The enzyme is soluble, in contrast to the particulate enzyme, EC 1.14.18.3.
  • Broad specificity; many alkanes can be hydroxylated, and alkenes are converted into the corresponding epoxides; CO is oxidized to CO(2), ammonia is oxidized to hydroxylamine, and some aromatic compounds and cyclic alkanes can also be hydroxylated, but more slowly.
Cross-references
BRENDA1.14.13.25
EC2PDB1.14.13.25
ExplorEnz1.14.13.25
PRIAM enzyme-specific profiles1.14.13.25
KEGG Ligand Database for Enzyme Nomenclature1.14.13.25
IUBMB Enzyme Nomenclature1.14.13.25
IntEnz1.14.13.25
MEDLINEFind literature relating to 1.14.13.25
MetaCyc1.14.13.25
Rhea expert-curated reactions1.14.13.25
UniProtKB/Swiss-Prot
P22869, MEMA_METCA;  P27353, MEMA_METTR;  P18798, MEMB_METCA;  
P27354, MEMB_METTR;  P11987, MEMG_METCA;  P27355, MEMG_METTR;  
P22868, MMOC_METCA;  Q53563, MMOC_METTR;  

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