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ENZYME

ENZYME entry: EC 1.14.13.253

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.253
Accepted Name
3-demethoxyubiquinone 3-hydroxylase (NADH)
Reaction catalysed
a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone + NADH + O2 = a 3-demethylubiquinone + NAD(+) + H2O
Comment(s)
  • The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone.
  • The vertebrate enzyme has no activity with 5-methoxy-2-methyl-3-(all- trans-polyprenyl)-1,4-benzoquinol (cf. EC 1.14.99.60).
  • The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Cross-references
BRENDA1.14.13.253
EC2PDB1.14.13.253
ExplorEnz1.14.13.253
KEGG Ligand Database for Enzyme Nomenclature1.14.13.253
IUBMB Enzyme Nomenclature1.14.13.253
MEDLINEFind literature relating to 1.14.13.253
MetaCyc1.14.13.253
Rhea expert-curated reactions1.14.13.253
UniProtKB/Swiss-Prot
Q2TBW2, COQ7_BOVINP48376, COQ7_CAEELQ54VB3, COQ7_DICDI
Q99807, COQ7_HUMANP97478, COQ7_MOUSEQ63619, COQ7_RAT
O74826, COQ7_SCHPOP41735, COQ7_YEAST

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