ENZYME entry: EC 1.14.13.50
Accepted Name |
pentachlorophenol monooxygenase.
|
Alternative Name(s) |
PCB4MO. |
PCB 4-monooxygenase. |
PCP hydroxylase. |
pentachlorophenol 4-monooxygenase. |
pentachlorophenol dechlorinase. |
pentachlorophenol dehalogenase. |
pentachlorophenol hydroxylase. |
Reaction catalysed |
- H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)
- 2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)
|
Comment(s) |
- The enzyme displaces a diverse range of substituents from the
4-position of polyhalogenated phenols but requires that a halogen
substituent be present at the 2-position.
- If C-4 carries a halogen substituent, reaction 1 is catalyzed; if C-4
is unsubstituted, reaction 2 is catalyzed.
|
Cross-references |
BRENDA | 1.14.13.50 |
EC2PDB | 1.14.13.50 |
ExplorEnz | 1.14.13.50 |
PRIAM enzyme-specific profiles | 1.14.13.50 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.50 |
IUBMB Enzyme Nomenclature | 1.14.13.50 |
IntEnz | 1.14.13.50 |
MEDLINE | Find literature relating to 1.14.13.50 |
MetaCyc | 1.14.13.50 |
Rhea expert-curated reactions | 1.14.13.50 |
UniProtKB/Swiss-Prot |
|
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