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ENZYME entry: EC 1.14.13.50

Accepted Name
Pentachlorophenol monooxygenase.
Alternative Name(s)
PCB 4-monooxygenase.
PCB4MO.
PCP hydroxylase.
Pentachlorophenol 4-monooxygenase.
Pentachlorophenol dechlorinase.
Pentachlorophenol dehalogenase.
Pentachlorophenol hydroxylase.
Reaction catalysed
  • Pentachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP(+) + chloride + H(2)O
  • 2,3,5,6-tetrachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position.
  • If C-4 carries a halogen substituent, reaction 1 is catalyzed; if C-4 is unsubstituted, reaction 2 is catalyzed.
Cross-references
BRENDA1.14.13.50
EC2PDB1.14.13.50
ExplorEnz1.14.13.50
PRIAM enzyme-specific profiles1.14.13.50
KEGG Ligand Database for Enzyme Nomenclature1.14.13.50
IUBMB Enzyme Nomenclature1.14.13.50
IntEnz1.14.13.50
MEDLINEFind literature relating to 1.14.13.50
MetaCyc1.14.13.50
Rhea expert-curated reactions1.14.13.50
UniProtKB/Swiss-Prot
P42535, PCPB_SPHCR

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