A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.13.50
| Accepted Name |
|---|
| Pentachlorophenol monooxygenase.
|
| Alternative Name(s) |
|---|
| PCB 4-monooxygenase. |
| PCB4MO. |
| PCP hydroxylase. |
| Pentachlorophenol 4-monooxygenase. |
| Pentachlorophenol dechlorinase. |
| Pentachlorophenol dehalogenase. |
| Pentachlorophenol hydroxylase. |
| Reaction catalysed |
|---|
- Pentachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP(+) + chloride + H(2)O
- 2,3,5,6-tetrachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H(2)O
|
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- The enzyme displaces a diverse range of substituents from the
4-position of polyhalogenated phenols but requires that a halogen
substituent be present at the 2-position.
- If C-4 carries a halogen substituent, reaction 1 is catalyzed; if C-4
is unsubstituted, reaction 2 is catalyzed.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.50 |
| EC2PDB | 1.14.13.50 |
| ExplorEnz | 1.14.13.50 |
| PRIAM enzyme-specific profiles | 1.14.13.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.50 |
| IUBMB Enzyme Nomenclature | 1.14.13.50 |
| IntEnz | 1.14.13.50 |
| MEDLINE | Find literature relating to 1.14.13.50 |
| MetaCyc | 1.14.13.50 |
| UniProtKB/Swiss-Prot |
|
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