Expasy logo

ENZYME

ENZYME entry: EC 1.14.13.8

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.8
Accepted Name
flavin-containing monooxygenase
Alternative Name(s)
dimethylaniline monooxygenase (N-oxide-forming)
dimethylaniline N-oxidase
dimethylaniline oxidase
DMA oxidase
FAD-containing monooxygenase
flavin mixed function oxidase
flavin monooxygenase
FMO
methylphenyltetrahydropyridine N-monooxygenase
mixed-function amine oxidase
N,N-dimethylaniline monooxygenase
Ziegler's enzyme
Reaction catalysed
N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O
Comment(s)
  • A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines.
  • Is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate.
  • Generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites.
  • For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP).
  • Formerly EC 1.13.12.11.
Cross-references
Rhea expert-curated reactions1.14.13.8
ExplorEnz1.14.13.8
IUBMB Enzyme Nomenclature1.14.13.8
UniProtKB/Swiss-Prot
Q95LA2, FMO1_CANLFQ01740, FMO1_HUMANP50285, FMO1_MOUSE
P16549, FMO1_PIGP17636, FMO1_RABITP36365, FMO1_RAT
Q28505, FMO2_MACMUP17635, FMO2_RABITQ8HYJ9, FMO3_BOVIN
Q95LA1, FMO3_CANLFP49328, FMO3_CAVPOP31513, FMO3_HUMAN
Q8SPQ7, FMO3_MACMUP97501, FMO3_MOUSEQ7YS44, FMO3_PANTR
P32417, FMO3_RABITQ9EQ76, FMO3_RATP49109, FMO5_CAVPO
P49326, FMO5_HUMANP97872, FMO5_MOUSEQ04799, FMO5_RABIT
Q8K4C0, FMO5_RAT
BRENDA1.14.13.8
MetaCyc1.14.13.8
KEGG Ligand Database for Enzyme Nomenclature1.14.13.8
MEDLINEFind literature relating to 1.14.13.8

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-