ID 1.14.13.83 DE precorrin-3B synthase. AN precorrin-3X synthase. CA 2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B. CC -!- An oxygen atom from dioxygen is incorporated into the macrocycle at CC C-20. CC -!- In the aerobic cobalamin biosynthesis pathway, four enzymes are CC involved in the conversion of precorrin-3A to precorrin-6A. CC -!- This enzyme carries out the first of the four steps, yielding CC precorrin-3B as the product. CC -!- This is followed by three methylation reactions, which introduce a CC methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and CC C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- CC 4, precorrin-5 and precorrin-6A, respectively. DR P21637, COBG_SINSX ; //