ID 1.14.14.105 DE taxane 10beta-hydroxylase. AN 5-alpha-taxadienol-10-beta-hydroxylase. AN CYP725A1. CA O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha- CA yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + CA H2O + oxidized [NADPH--hemoprotein reductase]. CC -!- This microsomal cytochrome-P450 (heme-thiolate) enzyme from the plant CC Taxus cuspidata is involved in the biosynthesis of the diterpenoid CC antineoplastic drug taxol (paclitaxel). CC -!- Formerly EC 1.14.13.76. DR Q9AXM6, T10H_TAXCU ; //