Home  |  Contact

ENZYME entry: EC 1.14.14.106

Accepted Name
Taxane 13-alpha-hydroxylase.
Alternative Name(s)
CYP725A2.
Reaction catalysed
Taxa-4(20),11-dien-5-alpha-ol + [reduced NADPH--hemoprotein reductase] + O(2) <=> taxa-4(20),11-dien-5-alpha,13-alpha-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This cytochrome-P450(heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
  • Formerly EC 1.14.13.77.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.106
EC2PDB1.14.14.106
ExplorEnz1.14.14.106
PRIAM enzyme-specific profiles1.14.14.106
KEGG Ligand Database for Enzyme Nomenclature1.14.14.106
IUBMB Enzyme Nomenclature1.14.14.106
IntEnz1.14.14.106
MEDLINEFind literature relating to 1.14.14.106
MetaCyc1.14.14.106
UniProtKB/Swiss-Prot
Q8W4T9, T13H_TAXCU

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-