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ENZYME

ENZYME entry: EC 1.14.14.107

Accepted Name
ent-kaurenoic acid monooxygenase
Alternative Name(s)
CYP88A3
ent-kaurenoic acid oxidase
Reaction catalysed
ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from plants.
  • Catalyzes three sucessive oxidations of ent-kaurenoic acid.
  • The second step includes a ring-B contraction giving the gibbane skeleton.
  • In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16- en-19-oate is also formed.
  • Formerly EC 1.14.13.79.
Cross-references
BRENDA1.14.14.107
EC2PDB1.14.14.107
ExplorEnz1.14.14.107
PRIAM enzyme-specific profiles1.14.14.107
KEGG Ligand Database for Enzyme Nomenclature1.14.14.107
IUBMB Enzyme Nomenclature1.14.14.107
IntEnz1.14.14.107
MEDLINEFind literature relating to 1.14.14.107
MetaCyc1.14.14.107
Rhea expert-curated reactions1.14.14.107
UniProtKB/Swiss-Prot
O23051, KAO1_ARATHQ9AXH9, KAO1_HORVUQ9C5Y2, KAO2_ARATH
Q5VRM7, KAO_ORYSJ

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