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ENZYME entry: EC 1.14.14.107

Accepted Name
Ent-kaurenoic acid monooxygenase.
Alternative Name(s)
CYP88A3.
Ent-kaurenoic acid oxidase.
Reaction catalysed
Ent-kaur-16-en-19-oate + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> gibberellin A(12) + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from plants.
  • Catalyzes three sucessive oxidations of ent-kaurenoic acid.
  • The second step includes a ring-B contraction giving the gibbane skeleton.
  • In pumpkin (Cucurbita maxima) ent-6-alpha,7-alpha-dihydroxykaur-16- en-19-oate is also formed.
  • Formerly EC 1.14.13.76.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.107
EC2PDB1.14.14.107
ExplorEnz1.14.14.107
PRIAM enzyme-specific profiles1.14.14.107
KEGG Ligand Database for Enzyme Nomenclature1.14.14.107
IUBMB Enzyme Nomenclature1.14.14.107
IntEnz1.14.14.107
MEDLINEFind literature relating to 1.14.14.107
MetaCyc1.14.14.107
UniProtKB/Swiss-Prot
O23051, KAO1_ARATH;  Q9AXH9, KAO1_HORVU;  Q9C5Y2, KAO2_ARATH;  
Q5VRM7, KAO_ORYSJ;  

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