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ENZYME

ENZYME entry: EC 1.14.14.108

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.108
Accepted Name
2,5-diketocamphane 1,2-monooxygenase
Alternative Name(s)
2,5-diketocamphane 1,2-monooxygenase oxygenating component
2,5-diketocamphane lactonizing enzyme
camphor 1,2-monooxygenase
camphor ketolactonase I
Reaction catalysed
(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H2O + H(+)
Comment(s)
  • A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid.
  • Involved in the degradation of (+)-camphor.
  • Requires a dedicated NADH-FMN reductase (cf. EC 1.5.1.42).
  • Can accept several bicyclic ketones including (+)- and (-)-camphor and adamantanone.
  • The product spontaneously converts to [(1R)-2,2,3-trimethyl-5- oxocyclopent-3-enyl]acetate.
  • Formerly EC 1.14.13.162 and EC 1.14.15.2.
Cross-references
BRENDA1.14.14.108
EC2PDB1.14.14.108
ExplorEnz1.14.14.108
KEGG Ligand Database for Enzyme Nomenclature1.14.14.108
IUBMB Enzyme Nomenclature1.14.14.108
MEDLINEFind literature relating to 1.14.14.108
MetaCyc1.14.14.108
Rhea expert-curated reactions1.14.14.108
UniProtKB/Swiss-Prot
Q6STM1, 25DK1_PSEPUM5AWY0, 25DK2_PSEPU

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