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ENZYME entry: EC 1.14.14.108

Accepted Name
2,5-diketocamphane 1,2-monooxygenase.
Alternative Name(s)
2,5-diketocamphane 1,2-monooxygenase oxygenating component.
2,5-diketocamphane lactonizing enzyme.
Camphor 1,2-monooxygenase.
Camphor ketolactonase I.
Reaction catalysed
(1R,4R)-bornane-2,5-dione + FMNH(2) + O(2) <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(2)O
Cofactor(s)
Fe cation.
Comment(s)
  • A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid.
  • Involved in the degradation of (+)-camphor.
  • Requires a dedicated NADH-FMN reductase (cf. EC 1.5.1.42).
  • Can accept several bicyclic ketones including (+)- and (-)-camphor and adamantanone.
  • The product spontaneously converts to ((1R)-2,2,3-trimethyl-5- oxocyclopent-3-enyl)acetate.
  • Formerly EC 1.14.13.162 and EC 1.14.15.2.
Cross-references
BRENDA1.14.14.108
EC2PDB1.14.14.108
ExplorEnz1.14.14.108
PRIAM enzyme-specific profiles1.14.14.108
KEGG Ligand Database for Enzyme Nomenclature1.14.14.108
IUBMB Enzyme Nomenclature1.14.14.108
IntEnz1.14.14.108
MEDLINEFind literature relating to 1.14.14.108
MetaCyc1.14.14.108
UniProtKB/Swiss-Prot
Q6STM1, 25DK1_PSEPU

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