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ENZYME entry: EC 1.14.14.114

Accepted Name
Amorpha-4,11-diene 12 monooxygenase.
Alternative Name(s)
CYP71AV1.
Reaction catalysed
Amorpha-4,11-diene + 3 O(2) + 3 [reduced NADPH--hemoprotein reductase] <=> artemisinate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Cloned from the plant Artemisia annua (sweet wormwood).
  • Part of the biosynthetic pathway of artemisinin.
  • Formerly EC 1.14.13.158.
Cross-references
BRENDA1.14.14.114
EC2PDB1.14.14.114
ExplorEnz1.14.14.114
PRIAM enzyme-specific profiles1.14.14.114
KEGG Ligand Database for Enzyme Nomenclature1.14.14.114
IUBMB Enzyme Nomenclature1.14.14.114
IntEnz1.14.14.114
MEDLINEFind literature relating to 1.14.14.114
MetaCyc1.14.14.114
Rhea expert-curated reactions1.14.14.114
UniProtKB/Swiss-Prot
Q1PS23, AMO_ARTAN

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