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ENZYME entry: EC 1.14.14.115

Accepted Name
11-oxo-beta-amyrin 30-oxidase.
Alternative Name(s)
11-oxo-beta-amyrin 30-monooxygenase.
CYP72A.
CYP72A154.
Reaction catalysed
11-oxo-beta-amyrin + 3 O(2) + 3 [reduced NADPH--hemoprotein reductase] <=> glycyrrhetinate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin.
  • The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin.
  • Formerly EC 1.14.13.173.
Cross-references
BRENDA1.14.14.115
EC2PDB1.14.14.115
ExplorEnz1.14.14.115
PRIAM enzyme-specific profiles1.14.14.115
KEGG Ligand Database for Enzyme Nomenclature1.14.14.115
IUBMB Enzyme Nomenclature1.14.14.115
IntEnz1.14.14.115
MEDLINEFind literature relating to 1.14.14.115
MetaCyc1.14.14.115
Rhea expert-curated reactions1.14.14.115
UniProtKB/Swiss-Prot
H1A988, C7254_GLYUR;  H1A981, C7263_MEDTR;  

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