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ENZYME entry: EC 1.14.14.116

Accepted Name
Averantin hydroxylase.
Alternative Name(s)
AVN hydroxylase.
CYP60A1.
Reaction catalysed
  • (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'R)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein isolated from the saprophytic mold Aspergillus parasiticus.
  • Involved in aflatoxin biosynthesis.
  • Does not react with (1'R)-averantin.
  • Formerly EC 1.14.13.174.
Cross-references
BRENDA1.14.14.116
EC2PDB1.14.14.116
ExplorEnz1.14.14.116
PRIAM enzyme-specific profiles1.14.14.116
KEGG Ligand Database for Enzyme Nomenclature1.14.14.116
IUBMB Enzyme Nomenclature1.14.14.116
IntEnz1.14.14.116
MEDLINEFind literature relating to 1.14.14.116
MetaCyc1.14.14.116
UniProtKB/Swiss-Prot
Q12732, AFLG_ASPPU;  M2YJD1, AVNA_DOTSN;  

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