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ENZYME entry: EC 1.14.14.12

Accepted Name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
Reaction catalysed
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O
Comment(s)
  • This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.
  • It can use either FADH or FMNH2 as flavin cofactor.
  • The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.
Cross-references
BRENDA1.14.14.12
EC2PDB1.14.14.12
ExplorEnz1.14.14.12
PRIAM enzyme-specific profiles1.14.14.12
KEGG Ligand Database for Enzyme Nomenclature1.14.14.12
IUBMB Enzyme Nomenclature1.14.14.12
IntEnz1.14.14.12
MEDLINEFind literature relating to 1.14.14.12
MetaCyc1.14.14.12
Rhea expert-curated reactions1.14.14.12
UniProtKB/Swiss-Prot
P9WJA0, HSAA_MYCTO;  P9WJA1, HSAA_MYCTU;  Q0S811, HSAA_RHOJR;  

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