ENZYME entry: EC 1.14.14.12
Accepted Name |
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
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Reaction catalysed |
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(2)O |
Comment(s) |
- This bacterial enzyme participates in the degradation of several
steroids, including cholesterol and testosterone.
- It can use either FADH or FMNH(2) as flavin cofactor.
- The enzyme forms a two-component system with a reductase (HsaB) that
utilizes NADH to reduce the flavin, which is then transferred to the
oxygenase subunit.
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Cross-references |
BRENDA | 1.14.14.12 |
EC2PDB | 1.14.14.12 |
ExplorEnz | 1.14.14.12 |
PRIAM enzyme-specific profiles | 1.14.14.12 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.12 |
IUBMB Enzyme Nomenclature | 1.14.14.12 |
IntEnz | 1.14.14.12 |
MEDLINE | Find literature relating to 1.14.14.12 |
MetaCyc | 1.14.14.12 |
Rhea expert-curated reactions | 1.14.14.12 |
UniProtKB/Swiss-Prot |
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