ENZYME

ENZYME entry: EC 1.14.14.12

Accepted Name

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.

Reaction catalysed

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(2)O

Comment(s)

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.
It can use either FADH or FMNH(2) as flavin cofactor.
The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.

Cross-references

BRENDA

1.14.14.12

EC2PDB

1.14.14.12

ExplorEnz

1.14.14.12

PRIAM enzyme-specific profiles

1.14.14.12

KEGG Ligand Database for Enzyme Nomenclature

1.14.14.12

IUBMB Enzyme Nomenclature

1.14.14.12

IntEnz

1.14.14.12

MEDLINE

Find literature relating to 1.14.14.12

MetaCyc

1.14.14.12

UniProtKB/Swiss-Prot

P9WJA0, HSAA_MYCTO;

P9WJA1, HSAA_MYCTU;

Q0S811, HSAA_RHOJR;

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