A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.14.12
| Accepted Name |
|---|
| 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
|
| Reaction catalysed |
|---|
| 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(2)O |
| Comment(s) |
|---|
- This bacterial enzyme participates in the degradation of several
steroids, including cholesterol and testosterone.
- It can use either FADH or FMNH(2) as flavin cofactor.
- The enzyme forms a two-component system with a reductase (HsaB) that
utilizes NADH to reduce the flavin, which is then transferred to the
oxygenase subunit.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.12 |
| EC2PDB | 1.14.14.12 |
| ExplorEnz | 1.14.14.12 |
| PRIAM enzyme-specific profiles | 1.14.14.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.12 |
| IUBMB Enzyme Nomenclature | 1.14.14.12 |
| IntEnz | 1.14.14.12 |
| MEDLINE | Find literature relating to 1.14.14.12 |
| MetaCyc | 1.14.14.12 |
| UniProtKB/Swiss-Prot |
|
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