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ENZYME

ENZYME entry: EC 1.14.14.12

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.12
Accepted Name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Reaction catalysed
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O + H(+)
Comment(s)
  • This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.
  • It can use either FADH or FMNH2 as flavin cofactor.
  • The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.
Cross-references
BRENDA1.14.14.12
EC2PDB1.14.14.12
ExplorEnz1.14.14.12
KEGG Ligand Database for Enzyme Nomenclature1.14.14.12
IUBMB Enzyme Nomenclature1.14.14.12
MEDLINEFind literature relating to 1.14.14.12
MetaCyc1.14.14.12
Rhea expert-curated reactions1.14.14.12
UniProtKB/Swiss-Prot
P9WJA0, HSAA_MYCTOP9WJA1, HSAA_MYCTUQ0S811, HSAA_RHOJR

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