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ENZYME entry: EC 1.14.14.124

Accepted Name
dihydromonacolin L hydroxylase.
Reaction catalysed
dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous.
  • The enzyme from fungi also catalyzes the reaction of EC 1.14.14.125.
  • Formerly EC 1.14.13.197.
Cross-references
BRENDA1.14.14.124
EC2PDB1.14.14.124
ExplorEnz1.14.14.124
PRIAM enzyme-specific profiles1.14.14.124
KEGG Ligand Database for Enzyme Nomenclature1.14.14.124
IUBMB Enzyme Nomenclature1.14.14.124
IntEnz1.14.14.124
MEDLINEFind literature relating to 1.14.14.124
MetaCyc1.14.14.124
Rhea expert-curated reactions1.14.14.124
UniProtKB/Swiss-Prot
Q9Y7C8, LOVA_ASPTE;  Q0C8M4, LOVA_ASPTN;  Q3S2T8, MOKC_MONPI;  

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