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ENZYME entry: EC 1.14.14.126
Accepted Name |
beta-amyrin 28-monooxygenase.
|
Alternative Name(s) |
beta-amyrin 28-oxidase. |
CYP16A75. |
CYP716A12. |
CYP716A52v2. |
Reaction catalysed |
beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] |
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein found in plants.
- The enzyme is involved in the biosynthesis of oleanane-type
triterpenoids, such as ginsenoside Ro.
- The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can
also convert alpha-amyrin and lupeol to ursolic acid and betulinic
acid, respectively.
- The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not
catalyze the reaction to completion, resulting in accumulation of
both intermediates.
- Formerly EC 1.14.13.201.
|
Cross-references |
BRENDA | 1.14.14.126 |
EC2PDB | 1.14.14.126 |
ExplorEnz | 1.14.14.126 |
PRIAM enzyme-specific profiles | 1.14.14.126 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.126 |
IUBMB Enzyme Nomenclature | 1.14.14.126 |
IntEnz | 1.14.14.126 |
MEDLINE | Find literature relating to 1.14.14.126 |
MetaCyc | 1.14.14.126 |
Rhea expert-curated reactions | 1.14.14.126 |
UniProtKB/Swiss-Prot |
|
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