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ENZYME entry: EC 1.14.14.126

Accepted Name
Beta-amyrin 28-monooxygenase.
Alternative Name(s)
Beta-amyrin 28-oxidase.
CYP16A75.
CYP716A12.
CYP716A52v2.
Reaction catalysed
Beta-amyrin + 3 O(2) + 3 [reduced NADPH--hemoprotein reductase] <=> oleanolate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro.
  • The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively.
  • The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyze the reaction to completion, resulting in accumulation of both intermediates.
  • Formerly EC 1.14.13.201.
Cross-references
BRENDA1.14.14.126
EC2PDB1.14.14.126
ExplorEnz1.14.14.126
PRIAM enzyme-specific profiles1.14.14.126
KEGG Ligand Database for Enzyme Nomenclature1.14.14.126
IUBMB Enzyme Nomenclature1.14.14.126
IntEnz1.14.14.126
MEDLINEFind literature relating to 1.14.14.126
MetaCyc1.14.14.126
UniProtKB/Swiss-Prot
Q2MJ20, C7A12_MEDTR;  F6H9N6, C7A15_VITVI;  A5BFI4, C7A17_VITVI;  
I7C6E8, C7A52_PANGI;  

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