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ENZYME

ENZYME entry: EC 1.14.14.126

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.126
Accepted Name
beta-amyrin 28-monooxygenase
Alternative Name(s)
beta-amyrin 28-oxidase
CYP16A75
CYP716A12
CYP716A52v2
Reaction catalysed
beta-amyrin + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = oleanolate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro.
  • The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively.
  • The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyze the reaction to completion, resulting in accumulation of both intermediates.
  • Formerly EC 1.14.13.201.
Cross-references
BRENDA1.14.14.126
EC2PDB1.14.14.126
ExplorEnz1.14.14.126
KEGG Ligand Database for Enzyme Nomenclature1.14.14.126
IUBMB Enzyme Nomenclature1.14.14.126
MEDLINEFind literature relating to 1.14.14.126
MetaCyc1.14.14.126
Rhea expert-curated reactions1.14.14.126
UniProtKB/Swiss-Prot
A0AAW1NEA3, C7168_SAPOFA0AAW1JA93, C7169_SAPOFQ2MJ20, C7A12_MEDTR
F6H9N6, C7A15_VITVIA5BFI4, C7A17_VITVIA0A3Q7HBJ5, C7A44_SOLLC
K4CEE8, C7A46_SOLLCI7C6E8, C7A52_PANGIA0A0U2U8U5, C7A81_BARVU
A0A0S2II38, C7A94_KALSE

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