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ENZYME entry: EC 1.14.14.131

Accepted Name
Bursehernin 5'-monooxygenase.
Alternative Name(s)
Bursehernin 5'-hydroxylase.
CYP71CU1.
Reaction catalysed
(-)-bursehernin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (-)-5'-demethylyatein + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum.
  • The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
  • Formerly EC 1.14.13.213.
Cross-references
BRENDA1.14.14.131
EC2PDB1.14.14.131
ExplorEnz1.14.14.131
PRIAM enzyme-specific profiles1.14.14.131
KEGG Ligand Database for Enzyme Nomenclature1.14.14.131
IUBMB Enzyme Nomenclature1.14.14.131
IntEnz1.14.14.131
MEDLINEFind literature relating to 1.14.14.131
MetaCyc1.14.14.131
Rhea expert-curated reactions1.14.14.131
UniProtKB/Swiss-Prot
A0A0N9HTU1, C71CU_SINHE

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