ENZYME entry: EC 1.14.14.131
Accepted Name |
Bursehernin 5'-monooxygenase.
|
Alternative Name(s) |
Bursehernin 5'-hydroxylase. |
CYP71CU1. |
Reaction catalysed |
(-)-bursehernin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (-)-5'-demethylyatein + [oxidized NADPH--hemoprotein reductase] + H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein characterized from the
plant Sinopodophyllum hexandrum.
- The enzyme is involved in the biosynthetic pathway of
podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are
important anticancer drugs.
- Formerly EC 1.14.13.213.
|
Cross-references |
BRENDA | 1.14.14.131 |
EC2PDB | 1.14.14.131 |
ExplorEnz | 1.14.14.131 |
PRIAM enzyme-specific profiles | 1.14.14.131 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.131 |
IUBMB Enzyme Nomenclature | 1.14.14.131 |
IntEnz | 1.14.14.131 |
MEDLINE | Find literature relating to 1.14.14.131 |
MetaCyc | 1.14.14.131 |
Rhea expert-curated reactions | 1.14.14.131 |
UniProtKB/Swiss-Prot |
|
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