ENZYME entry: EC 1.14.14.131
| Accepted Name |
|---|
| Bursehernin 5'-monooxygenase.
|
| Alternative Name(s) |
|---|
| Bursehernin 5'-hydroxylase. |
| CYP71CU1. |
| Reaction catalysed |
|---|
| (-)-bursehernin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (-)-5'-demethylyatein + [oxidized NADPH--hemoprotein reductase] + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- A cytochrome P450 (heme-thiolate) protein characterized from the
plant Sinopodophyllum hexandrum.
- The enzyme is involved in the biosynthetic pathway of
podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are
important anticancer drugs.
- Formerly EC 1.14.13.213.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.131 |
| EC2PDB | 1.14.14.131 |
| ExplorEnz | 1.14.14.131 |
| PRIAM enzyme-specific profiles | 1.14.14.131 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.131 |
| IUBMB Enzyme Nomenclature | 1.14.14.131 |
| IntEnz | 1.14.14.131 |
| MEDLINE | Find literature relating to 1.14.14.131 |
| MetaCyc | 1.14.14.131 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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