ID   1.14.14.132
DE   (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase.
AN   CYP82D61.
CA   (-)-4'-desmethyl-deoxypodophyllotoxin + reduced [NADPH--hemoprotein
CA   reductase] + O2 = 4'-demethylepipodophyllotoxin + oxidized [NADPH-
CA   -hemoprotein reductase] + H2O + H(+).
CC   -!- A cytochrome P450 (heme-thiolate) protein characterized from the
CC       plant Sinopodophyllum hexandrum.
CC   -!- The enzyme produces the direct precursor to etoposide, a potent
CC       anticancer drug.
CC   -!- It can also act on (-)-deoxypodophyllotoxin with lower efficiency.
CC   -!- Formerly EC 1.14.13.214.
DR   A0A0N7F297, C82D6_SINHE;
//