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ENZYME

ENZYME entry: EC 1.14.14.137

Accepted Name
(+)-abscisic acid 8'-hydroxylase
Alternative Name(s)
(+)-ABA 8'-hydroxylase
ABA 8'-hydroxylase
CYP707A1
Reaction catalysed
2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Catalyzes the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone.
  • CO inhibits the reaction, but its effects can be reversed by the presence of blue light.
  • The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.
  • Formerly EC 1.14.13.93.
Cross-references
BRENDA1.14.14.137
EC2PDB1.14.14.137
ExplorEnz1.14.14.137
PRIAM enzyme-specific profiles1.14.14.137
KEGG Ligand Database for Enzyme Nomenclature1.14.14.137
IUBMB Enzyme Nomenclature1.14.14.137
IntEnz1.14.14.137
MEDLINEFind literature relating to 1.14.14.137
MetaCyc1.14.14.137
Rhea expert-curated reactions1.14.14.137
UniProtKB/Swiss-Prot
Q949P1, ABAH1_ARATHQ09J79, ABAH1_ORYSIQ05JG2, ABAH1_ORYSJ
A9QNE7, ABAH1_SOLLCO81077, ABAH2_ARATHQ09J78, ABAH2_ORYSI
Q6ZDE3, ABAH2_ORYSJK4CI52, ABAH2_SOLLCQ9FH76, ABAH3_ARATH
A2Z212, ABAH3_ORYSIQ0J185, ABAH3_ORYSJQ9LJK2, ABAH4_ARATH

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