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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.14.137

Accepted Name
(+)-abscisic acid 8'-hydroxylase.
Alternative Name(s)
(+)-ABA 8'-hydroxylase.
ABA 8'-hydroxylase.
CYP707A1.
Reaction catalysed
(+)-abscisate + [reduced NADPH--hemoprotein reductase] + O(2) <=> 8'-hydroxyabscisate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Catalyzes the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone.
  • CO inhibits the reaction, but its effects can be reversed by the presence of blue light.
  • The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.
  • Formerly EC 1.14.13.93.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.137
EC2PDB1.14.14.137
ExplorEnz1.14.14.137
PRIAM enzyme-specific profiles1.14.14.137
KEGG Ligand Database for Enzyme Nomenclature1.14.14.137
IUBMB Enzyme Nomenclature1.14.14.137
IntEnz1.14.14.137
MEDLINEFind literature relating to 1.14.14.137
MetaCyc1.14.14.137
UniProtKB/Swiss-Prot
Q949P1, ABAH1_ARATH;  Q09J79, ABAH1_ORYSI;  Q05JG2, ABAH1_ORYSJ;  
A9QNE7, ABAH1_SOLLC;  O81077, ABAH2_ARATH;  Q09J78, ABAH2_ORYSI;  
Q6ZDE3, ABAH2_ORYSJ;  K4CI52, ABAH2_SOLLC;  Q9FH76, ABAH3_ARATH;  
A2Z212, ABAH3_ORYSI;  Q0J185, ABAH3_ORYSJ;  Q9LJK2, ABAH4_ARATH;  

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