ID   1.14.14.139
DE   5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase.
AN   5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase.
AN   7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase.
AN   7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase.
AN   chenodeoxycholate 12alpha monooxygenase.
AN   CYP8B1.
AN   sterol 12alpha-hydroxylase.
CA   (1) 5beta-cholestane-3alpha,7alpha-diol + reduced [NADPH--hemoprotein
CA   reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + oxidized
CA   [NADPH--hemoprotein reductase] + H2O + H(+).
CA   (2) 7alpha-hydroxycholest-4-en-3-one + reduced [NADPH--hemoprotein
CA   reductase] + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + oxidized
CA   [NADPH--hemoprotein reductase] + H2O + H(+).
CA   (3) chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 =
CA   cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
CC   -!- A cytochrome P450 (heme-thiolate) protein found in mammals.
CC   -!- This is the key enzyme in the biosynthesis of the bile acid cholate.
CC   -!- The enzyme can also hydroxylate 5beta-cholestane-3alpha,7alpha-diol
CC       at the 25 and 26 position, but to a lesser extent.
CC   -!- Formerly EC 1.14.13.96 and EC 1.14.18.8.
DR   Q9UNU6, CP8B1_HUMAN;  O88962, CP8B1_MOUSE;  Q7YRB2, CP8B1_PIG  ;
DR   O02766, CP8B1_RABIT;
//