ID   1.14.14.14
DE   aromatase.
AN   CYP19A1.
AN   estrogen synthetase.
CA   (1) 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone =
CA   17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH-
CA   -hemoprotein reductase].
CA   (2) androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein
CA   reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH-
CA   -hemoprotein reductase].
CC   -!- The enzyme catalyzes three sequential hydroxylations of the androgens
CC       androst-4-ene-3,17-dione and testosterone, resulting in their
CC       aromatization and forming the estrogens estrone and 17beta-estradiol,
CC       respectively.
DR   O42145, C19AA_DANRE;  P79690, CP191_CARAU;  O73686, CP192_CARAU;
DR   P79430, CP192_PIG  ;  P79304, CP193_PIG  ;  Q6QHT9, CP19A_ANGJA;
DR   P46194, CP19A_BOVIN;  Q95M61, CP19A_CALJA;  Q5QQX7, CP19A_CANLF;
DR   Q6YI21, CP19A_CAPHI;  P19098, CP19A_CHICK;  P79699, CP19A_COTJA;
DR   O46512, CP19A_HORSE;  P11511, CP19A_HUMAN;  Q92111, CP19A_ICTPU;
DR   Q69FB6, CP19A_LAGAC;  P28649, CP19A_MOUSE;  P70091, CP19A_ORENI;
DR   Q92087, CP19A_ORYLA;  Q29624, CP19A_PIG  ;  Q29605, CP19A_RABIT;
DR   P22443, CP19A_RAT  ;  Q9XS28, CP19A_SHEEP;  Q92112, CP19A_TAEGU;
//