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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.14.141

Accepted Name
Psoralen synthase.
Reaction catalysed
(+)-marmesin + [reduced NADPH--hemoprotein reductase] + O(2) <=> psoralen + [oxidized NADPH--hemoprotein reductase] + acetone + 2 H(2)O
Comment(s)
  • This microsomal cytochrome P450 (heme-thiolate) enzyme is rather specific for (+)-marmesin, although it can also accept 5-hydroxymarmesin to a much lesser extent.
  • Furanocoumarins protect plants from fungal invasion and herbivore attack.
  • (+)-columbianetin, the angular furanocoumarin analog of the linear furanocoumarin (+)-marmesin, acts as a competitive inhibitor even though it is not a substrate.
  • Formerly EC 1.14.13.102.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.141
EC2PDB1.14.14.141
ExplorEnz1.14.14.141
PRIAM enzyme-specific profiles1.14.14.141
KEGG Ligand Database for Enzyme Nomenclature1.14.14.141
IUBMB Enzyme Nomenclature1.14.14.141
IntEnz1.14.14.141
MEDLINEFind literature relating to 1.14.14.141
MetaCyc1.14.14.141
UniProtKB/Swiss-Prot
Q6QNI4, C71AJ_AMMMJ;  C0SJS4, C71AJ_APIGR;  C0SJS2, C71AJ_PASSA;  

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