ID 1.14.14.143 DE (+)-menthofuran synthase. AN (+)-MFS. AN (+)-pulegone 9-hydroxylase. AN menthofuran synthase. CA (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)- CA menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]. CC -!- A cytochrome P450 (heme-thiolate) protein. CC -!- The conversion of substrate into product involves the hydroxylation CC of the syn-methyl (C9), intramolecular cyclization to the hemiketal CC and dehydration to the furan. CC -!- This is the second cytochrome P450-mediated step of monoterpene CC metabolism in peppermint, with the other step being catalyzed by CC EC 1.14.14.99. CC -!- Formerly EC 1.14.13.104. DR Q947B7, MFS_MENPI ; //