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ENZYME entry: EC 1.14.14.145

Accepted Name
Abieta-7,13-dien-18-ol hydroxylase.
Alternative Name(s)
Abietadienol hydroxylase.
CYP720B1.
Reaction catalysed
Abieta-7,13-dien-18-ol + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> abieta-7,13-dien-18-oate + 2 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • This enzyme catalyzes a step in the pathway of abietic acid biosynthesis.
  • The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine), and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine).
  • The recombinant enzyme catalyzes the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15- dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal.
  • It is not able to oxidize abietadiene.
  • Formerly EC 1.14.13.109.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.145
EC2PDB1.14.14.145
ExplorEnz1.14.14.145
PRIAM enzyme-specific profiles1.14.14.145
KEGG Ligand Database for Enzyme Nomenclature1.14.14.145
IUBMB Enzyme Nomenclature1.14.14.145
IntEnz1.14.14.145
MEDLINEFind literature relating to 1.14.14.145
MetaCyc1.14.14.145
Rhea expert-curated reactions1.14.14.145
UniProtKB/Swiss-Prot
Q50EK6, C72B1_PINTA

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