ID   1.14.14.150
DE   costunolide synthase.
AN   CYP71BL2.
CA   germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein
CA   reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein
CA   reductase].
CC   -!- A cytochrome P450 (heme-thiolate) protein from chicory plants.
CC   -!- The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-
CC       12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate,
CC       which spontaneously cyclises to form the lactone ring.
CC   -!- Formerly EC 1.14.13.120.
DR   F8S1I0, C7BL2_LACSA;  X2JE85, C7BL2_TANPA;  G3GBK0, C7BL3_CICIN;
//