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ENZYME entry: EC 1.14.14.161

Accepted Name
Nepetalactol monooxygenase.
Alternative Name(s)
CYP76A26.
Iridoid oxidase.
Reaction catalysed
(+)-cis,trans-nepetalactol + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> 7-deoxyloganetate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Comment(s)
  • The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P450 (heme thiolate) protein.
  • It catalyzes three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
Cross-references
BRENDA1.14.14.161
EC2PDB1.14.14.161
ExplorEnz1.14.14.161
PRIAM enzyme-specific profiles1.14.14.161
KEGG Ligand Database for Enzyme Nomenclature1.14.14.161
IUBMB Enzyme Nomenclature1.14.14.161
IntEnz1.14.14.161
MEDLINEFind literature relating to 1.14.14.161
MetaCyc1.14.14.161
UniProtKB/Swiss-Prot
W8JIS5, IO_CATRO

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