ID   1.14.14.168
DE   germacreene A acid 8beta-hydroxylase.
AN   CYP71BL1.
AN   CYP71BL6.
CA   germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein
CA   reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) +
CA   H2O + oxidized [NADPH--hemoprotein reductase].
CC   -!- A cytochrome P450 (heme-thiolate) protein from the plant Helianthus
CC       annuus (common sunflower).
CC   -!- The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-
CC       oate to inunolide (12,8beta) does not seem to occur spontaneously.
CC   -!- The enzyme from Inula hupehensis also forms some 8alpha-
CC       hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously
CC       cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170).
DR   F8S1H3, C7BL1_HELAN;  A0A2H4DGV8, C7BL6_INUHU;
//