ID   1.14.14.176
DE   taxadiene 5alpha-hydroxylase.
CA   taxa-4(5),11(12)-diene + reduced [NADPH--hemoprotein reductase] + O2 =
CA   taxa-4(20),11-dien-5alpha-ol + oxidized [NADPH--hemoprotein reductase] +
CA   H2O + H(+).
CC   -!- This microsomal cytochrome-P450 (heme-thiolate) enzyme is involved in
CC       the biosynthesis of the diterpenoid antineoplastic drug taxol
CC       (paclitaxel).
CC   -!- The reaction includes rearrangement of the 4(5)-double bond to a
CC       4(20)-double bond, possibly through allylic oxidation.
CC   -!- Formerly EC 1.14.99.37.
DR   Q6WG30, T5H_TAXCU  ;
//