ID   1.14.14.18
DE   heme oxygenase (biliverdin-producing).
AN   heme oxidase.
AN   heme oxygenase.
AN   heme oxygenase (decyclizing).
CA   heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin
CA   IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein
CA   reductase].
CC   -!- This mammalian enzyme participates in the degradation of heme.
CC   -!- The terminal oxygen atoms that are incorporated into the carbonyl
CC       groups of pyrrole rings A and B of biliverdin are derived from two
CC       separate oxygen molecules.
CC   -!- The third oxygen molecule provides the oxygen atom that converts the
CC       alpha-carbon to CO.
CC   -!- The enzyme requires NAD(P)H and EC 1.6.2.4. cf. EC 1.14.15.20.
CC   -!- Formerly EC 1.14.99.3.
DR   C3PAD1, HDOX_BACAA ;  C3L7Z8, HDOX_BACAC ;  A0RJE3, HDOX_BACAH ;
DR   Q81L50, HDOX_BACAN ;  B7JR48, HDOX_BACC0 ;  Q72ZK2, HDOX_BACC1 ;
DR   B7IJU1, HDOX_BACC2 ;  C1ETY1, HDOX_BACC3 ;  B7HF56, HDOX_BACC4 ;
DR   B7HRI4, HDOX_BACC7 ;  B9J044, HDOX_BACCQ ;  Q812Q3, HDOX_BACCR ;
DR   Q633Q1, HDOX_BACCZ ;  Q6HCY5, HDOX_BACHK ;  A9VJK2, HDOX_BACMK ;
DR   Q9K7R6, HDOX_HALH5 ;  Q7AP29, HDOX_LISIN ;  C1KZZ5, HDOX_LISMC ;
DR   Q723G7, HDOX_LISMF ;  B8DCJ3, HDOX_LISMH ;  Q92EH3, HDOX_LISMO ;
DR   A0AFT8, HDOX_LISW6 ;  Q5WCF2, HDOX_SHOC1 ;  O31534, HMOA_BACSU ;
DR   P38049, HMOB_BACSU ;  O48782, HMOX1_ARATH;  Q5E9F2, HMOX1_BOVIN;
DR   P14791, HMOX1_CHICK;  P09601, HMOX1_HUMAN;  P14901, HMOX1_MOUSE;
DR   Q69XJ4, HMOX1_ORYSJ;  P32394, HMOX1_PIG  ;  Q5R7E3, HMOX1_PONAB;
DR   P06762, HMOX1_RAT  ;  P30519, HMOX2_HUMAN;  Q2PG53, HMOX2_MACFA;
DR   O70252, HMOX2_MOUSE;  P43242, HMOX2_RABIT;  P23711, HMOX2_RAT  ;
DR   Q9C9L4, HMOX3_ARATH;  O70453, HMOX3_RAT  ;  Q9LQC0, HMOX4_ARATH;
DR   O73688, HMOX_TAKRU ;  P71119, HMUO_CORDI ;  Q8YVS7, HO1_NOSS1  ;
DR   P72849, HO1_SYNY3  ;  P74133, HO2_SYNY3  ;  O78497, HO_GUITH   ;
DR   Q1XDL5, HO_NEOYE   ;  P51271, HO_PORPU   ;  O19998, HO_RHOVL   ;
DR   A0A0H2XEA6, HO_XANC8   ;
//