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ENZYME

ENZYME entry: EC 1.14.14.182

Accepted Name
taxoid 7beta-hydroxylase
Reaction catalysed
  • O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from the yew tree Taxus cuspidata.
  • Does not act on earlier intermediates in taxol biosynthesis.
  • Formerly EC 1.14.13.147.
Cross-references
BRENDA1.14.14.182
EC2PDB1.14.14.182
ExplorEnz1.14.14.182
PRIAM enzyme-specific profiles1.14.14.182
KEGG Ligand Database for Enzyme Nomenclature1.14.14.182
IUBMB Enzyme Nomenclature1.14.14.182
IntEnz1.14.14.182
MEDLINEFind literature relating to 1.14.14.182
MetaCyc1.14.14.182
Rhea expert-curated reactions1.14.14.182
UniProtKB/Swiss-Prot
Q6JTJ0, T7BH_TAXCU

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