ID   1.14.14.19
DE   steroid 17alpha-monooxygenase.
AN   CYP17.
AN   CYP17A1.
AN   cytochrome p450 XVIIA1.
AN   steroid 17alpha-hydroxylase.
AN   steroid 17alpha-hydroxylase/17,20 lyase.
CA   a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-
CA   hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein
CA   reductase].
CC   -!- Requires NADPH and EC 1.6.2.4.
CC   -!- Catalyzes two independent reactions at the same active site - the
CC       17alpha-hydroxylation of pregnenolone and progesterone, which is part
CC       of glucocorticoid hormones biosynthesis, and the conversion of the
CC       17alpha-hydroxylated products via a 17,20-lyase reaction to form
CC       androstenedione and dehydroepiandrosterone, leading to sex hormone
CC       biosynthesis (EC 1.14.14.32).
CC   -!- The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an
CC       important factor in determining the directions of steroid hormone
CC       biosynthesis toward biosynthesis of glucocorticoid or sex hormones.
CC   -!- Formerly EC 1.14.1.7, EC 1.14.99.9 and EC 1.99.1.9.
DR   Q9GMC7, CP17A_BISBI;  P05185, CP17A_BOVIN;  Q9N0U7, CP17A_CAPHI;
DR   Q64410, CP17A_CAVPO;  P12394, CP17A_CHICK;  Q9GMC8, CP17A_FELCA;
DR   Q95328, CP17A_HORSE;  P05093, CP17A_HUMAN;  O73853, CP17A_ICTPU;
DR   Q2XVA1, CP17A_MACFA;  Q8HYM9, CP17A_MACMU;  P70687, CP17A_MESAU;
DR   P27786, CP17A_MOUSE;  P30437, CP17A_ONCMY;  P70085, CP17A_ORYLA;
DR   Q8HYN1, CP17A_PANTR;  Q8HYN0, CP17A_PAPCY;  Q9GLD2, CP17A_PAPHU;
DR   Q91Z85, CP17A_PERLE;  P19100, CP17A_PIG  ;  O57525, CP17A_RANDY;
DR   P11715, CP17A_RAT  ;  Q29497, CP17A_SHEEP;  Q92113, CP17A_SQUAC;
//