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ENZYME

ENZYME entry: EC 1.14.14.191

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.191
Accepted Name
taxane oxetanase 1
Reaction catalysed
taxa-4(20),11-dien-5alpha-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = 5,20-epoxytaxa-11-en-4alpha-yl acetate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme thiolate) enzyme.
  • Demonstrated in the plant Taxus mairei (Maire's yew).
  • It is involved in the biosynthesis of taxol (paclitaxel).
  • The reaction involves epoxidation of the 4(20)-double bond followed by rearangement giving the oxetane ring.
  • The reaction was demonstrated using taxa-4(20),11-diene- 2alpha,5alpha,7beta,9alpha,10beta,13alpha-hexayl hexaacetate.
Cross-references
Rhea expert-curated reactions1.14.14.191
ExplorEnz1.14.14.191
IUBMB Enzyme Nomenclature1.14.14.191
UniProtKB/Swiss-Prot
A0AA38FCJ6, TOT1_TAXCH
BRENDA1.14.14.191
MetaCyc1.14.14.191
KEGG Ligand Database for Enzyme Nomenclature1.14.14.191
MEDLINEFind literature relating to 1.14.14.191

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