ID   1.14.14.191
DE   taxane oxetanase 1.
CA   taxa-4(20),11-dien-5alpha-yl acetate + reduced [NADPH--hemoprotein
CA   reductase] + O2 = 5,20-epoxytaxa-11-en-4alpha-yl acetate + oxidized
CA   [NADPH--hemoprotein reductase] + H2O + H(+).
CC   -!- A cytochrome P450 (heme thiolate) enzyme.
CC   -!- Demonstrated in the plant Taxus mairei (Maire's yew).
CC   -!- It is involved in the biosynthesis of taxol (paclitaxel).
CC   -!- The reaction involves epoxidation of the 4(20)-double bond followed
CC       by rearangement giving the oxetane ring.
CC   -!- The reaction was demonstrated using taxa-4(20),11-diene-
CC       2alpha,5alpha,7beta,9alpha,10beta,13alpha-hexayl hexaacetate.
DR   A0AA38FCJ6, TOT1_TAXCH ;
//