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ENZYME

ENZYME entry: EC 1.14.14.195

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.195
Accepted Name
littorine mutase
Alternative Name(s)
CYP80F1
Reaction catalysed
(R)-littorine + reduced [NADPH--hemoprotein reductase] + O2 = hyoscyamine aldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Comment(s)
  • Isolated from the plants Hyoscyamus niger (black henbane) and Anisodus acutangulus.
  • Involved in the biosynthesis of the alkaloids hyoscyamine (atropine) and scopalamine.
  • The reaction involves hydroxylation of littorine, giving a 1,2-diol that undergoes a spontaneous dehydration accompanied by pinacol rearrangement.
Cross-references
Rhea expert-curated reactions1.14.14.195
ExplorEnz1.14.14.195
IUBMB Enzyme Nomenclature1.14.14.195
UniProtKB/Swiss-Prot
A0A024CI64, C80F1_ATRBEQ1A1B0, C80F1_HYONI
BRENDA1.14.14.195
MetaCyc1.14.14.195
KEGG Ligand Database for Enzyme Nomenclature1.14.14.195
MEDLINEFind literature relating to 1.14.14.195

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