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ENZYME entry: EC 1.14.14.20

Accepted Name
Phenol 2-monooxygenase (FADH(2)).
Reaction catalysed
Phenol + FADH(2) + O(2) <=> catechol + FAD + H(2)O
Comment(s)
  • The enzyme catalyzes the ortho-hydroxylation of simple phenols into the corresponding catechols.
  • It accepts 4-methylphenol, 4-chlorophenol, and 4-fluorophenol as well as 4-nitrophenol, 3-nitrophenol, and resorcinol.
  • The enzyme is part of a two-component system that also includes an NADH-dependent flavin reductase.
  • It is strictly dependent on FADH(2) and does not accept FMNH(2).
  • Cf. EC 1.14.13.7.
Cross-references
BRENDA1.14.14.20
EC2PDB1.14.14.20
ExplorEnz1.14.14.20
PRIAM enzyme-specific profiles1.14.14.20
KEGG Ligand Database for Enzyme Nomenclature1.14.14.20
IUBMB Enzyme Nomenclature1.14.14.20
IntEnz1.14.14.20
MEDLINEFind literature relating to 1.14.14.20
MetaCyc1.14.14.20

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