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ENZYME entry: EC 1.14.14.22

Accepted Name
dibenzothiophene sulfone monooxygenase.
Reaction catalysed
dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)
Comment(s)
  • This bacterial enzyme catalyzes a step in the desulfurization pathway of dibenzothiophenes.
  • The enzyme forms a two-component system with EC 1.5.1.42, which also interacts with EC 1.14.14.21.
  • The flavin-N(5)-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
Cross-references
BRENDA1.14.14.22
EC2PDB1.14.14.22
ExplorEnz1.14.14.22
PRIAM enzyme-specific profiles1.14.14.22
KEGG Ligand Database for Enzyme Nomenclature1.14.14.22
IUBMB Enzyme Nomenclature1.14.14.22
IntEnz1.14.14.22
MEDLINEFind literature relating to 1.14.14.22
MetaCyc1.14.14.22
Rhea expert-curated reactions1.14.14.22
UniProtKB/Swiss-Prot
Q0ZIH7, DSZA_RHOER;  P54995, DSZA_RHOSG;  Q6WNP3, DSZA_RHOSH;  

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