ID   1.14.14.24
DE   vitamin D 25-hydroxylase.
AN   CYP2R1.
AN   vitamin D2 25-hydroxylase.
AN   vitamin D3 25-hydroxylase.
CA   calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+)
CA   + H2O + oxidized [NADPH--hemoprotein reductase].
CC   -!- A microsomal enzyme isolated from human and mouse liver that
CC       bioactivates vitamin D3.
CC   -!- While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and
CC       CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is
CC       thought to catalyze the reaction in humans in vivo.
CC   -!- The direct electron donor to the enzyme is EC 1.6.2.4.
CC   -!- Formerly EC 1.14.13.159.
DR   O46658, CP2DP_PIG  ;  Q6VVX0, CP2R1_HUMAN;  Q6VVW9, CP2R1_MOUSE;
//