ID   1.14.14.25
DE   cholesterol 24-hydroxylase.
AN   cholesterol 24-monooxygenase.
AN   cholesterol 24S-hydroxylase.
AN   CYP46A1.
AN   cytochrome P450 46A1.
CA   cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-
CA   hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein
CA   reductase].
CC   -!- The enzyme can also produce 25-hydroxycholesterol.
CC   -!- In addition, it can further hydroxylate the product to 24,25-
CC       dihydroxycholesterol and 24,27-dihydroxycholesterol.
CC   -!- This reaction is the first step in the enzymic degradation of
CC       cholesterol in the brain as hydroxycholesterol can pass the blood-
CC       brain barrier whereas cholesterol cannot.
CC   -!- The direct electron donor to the enzyme is EC 1.6.2.4.
CC   -!- Formerly EC 1.14.13.98.
DR   Q9Y6A2, CP46A_HUMAN;  Q9WVK8, CP46A_MOUSE;
//