ID   1.14.14.29
DE   25/26-hydroxycholesterol 7alpha-hydroxylase.
AN   25-hydroxycholesterol 7alpha-hydroxylase.
AN   25-hydroxycholesterol 7alpha-monooxygenase.
AN   27-hydroxycholesterol 7alpha-hydroxylase.
AN   27-hydroxycholesterol 7-monooxygenase.
CA   (1) 25-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 =
CA   7alpha,25-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase]
CA   + H2O + H(+).
CA   (2) (25R)-cholest-5-ene-3beta,26-diol + reduced [NADPH--hemoprotein
CA   reductase] + O2 = (25R)-cholest-5-en-3beta,7alpha,26-triol + oxidized
CA   [NADPH--hemoprotein reductase] + H2O + H(+).
CC   -!- Unlike EC 1.14.14.26, which is specific for its oxysterol substrate,
CC       this enzyme can also metabolize the oxysterols 24,25-
CC       epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol,
CC       but to a lesser extent.
CC   -!- The direct electron donor to the enzyme is EC 1.6.2.4.
CC   -!- Formerly EC 1.14.13.60 and EC 1.14.13.100.
DR   O75881, CP7B1_HUMAN;  Q60991, CP7B1_MOUSE;  Q63688, CP7B1_RAT  ;
//