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ENZYME entry: EC 1.14.14.30

Accepted Name
Isobutylamine N-monooxygenase.
Reaction catalysed
  • 2-methylpropan-1-amine + FADH(2) + O(2) <=> N-(2-methylpropyl)hydroxylamine + FAD + H(2)O
  • 2-methylpropan-1-amine + FMNH(2) + O(2) <=> N-(2-methylpropyl)hydroxylamine + FMN + H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces viridifaciens, is part of a two component system that also includes a flavin reductase, which provides reduced flavin mononucleotide for this enzyme.
  • The enzyme, which is involved in the biosynthesis of the azoxy antibiotic valanimycin, has a similar activity with either FMNH(2) or FADH(2).
  • It exhibits broad specificity, and also accepts propan-1-amine, butan-1-amine, butan-2-amine and benzylamine.
Cross-references
BRENDA1.14.14.30
EC2PDB1.14.14.30
ExplorEnz1.14.14.30
PRIAM enzyme-specific profiles1.14.14.30
KEGG Ligand Database for Enzyme Nomenclature1.14.14.30
IUBMB Enzyme Nomenclature1.14.14.30
IntEnz1.14.14.30
MEDLINEFind literature relating to 1.14.14.30
MetaCyc1.14.14.30
UniProtKB/Swiss-Prot
P96072, VLMH_STRVF

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