ID   1.14.14.38
DE   valine N-monooxygenase.
AN   CYP79D1.
AN   CYP79D2.
CA   L-valine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-2-
CA   methylpropanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 +
CA   3 H2O + 2 H(+).
CC   -!- This enzyme catalyzes two successive N-hydroxylations of L-valine,
CC       the committed step in the biosynthesis of the cyanogenic glucoside
CC       linamarin in Manihot esculenta (cassava).
CC   -!- The product of the two hydroxylations, N,N-dihydroxy-L-valine,
CC       is labile and undergoes dehydration and decarboxylation that produce
CC       the (E) isomer of the oxime.
CC   -!- It is still not known whether the decarboxylation is spontaneous or
CC       catalyzed by the enzyme.
CC   -!- The enzyme can also accept L-isoleucine as substrate, with a lower
CC       activity.
CC   -!- It is different from EC 1.14.14.39.
CC   -!- Formerly EC 1.14.13.118.
DR   Q9M7B8, C79D1_MANES;  Q9M7B7, C79D2_MANES;  Q6J541, C79D3_LOTJA;
DR   Q6J540, C79D4_LOTJA;
//