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ENZYME entry: EC 1.14.14.40

Accepted Name
Phenylalanine N-monooxygenase.
Alternative Name(s)
CYP79A2.
CYP79D16.
Phenylalanine N-hydroxylase.
Reaction catalysed
L-phenylalanine + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> (E)-phenylacetaldoxime + 2 [oxidized NADPH--hemoprotein reductase] + CO(2) + 3 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This enzyme, found in plants, catalyzes two successive N-hydroxylations of L-phenylalanine, a committed step in the biosynthesis of benzylglucosinolate and the cyanogenic glucosides (R)-prunasin and (R)-amygdalin.
  • The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is labile and undergoes dehydration followed by decarboxylation, producing an oxime.
  • It is still not known whether the decarboxylation is spontaneous or catalyzed by the enzyme.
  • Formerly EC 1.14.13.124.
Cross-references
BRENDA1.14.14.40
EC2PDB1.14.14.40
ExplorEnz1.14.14.40
PRIAM enzyme-specific profiles1.14.14.40
KEGG Ligand Database for Enzyme Nomenclature1.14.14.40
IUBMB Enzyme Nomenclature1.14.14.40
IntEnz1.14.14.40
MEDLINEFind literature relating to 1.14.14.40
MetaCyc1.14.14.40
UniProtKB/Swiss-Prot
A0A068Q7V0, C7916_PRUMU;  Q9FLC8, C79A2_ARATH;  

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