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ENZYME entry: EC

Accepted Name
phenylalanine N-monooxygenase.
Alternative Name(s)
phenylalanine N-hydroxylase.
Reaction catalysed
L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
  • This enzyme, found in plants, catalyzes two successive N-hydroxylations of L-phenylalanine, a committed step in the biosynthesis of benzylglucosinolate and the cyanogenic glucosides (R)-prunasin and (R)-amygdalin.
  • The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is labile and undergoes dehydration followed by decarboxylation, producing an oxime.
  • It is still not known whether the decarboxylation is spontaneous or catalyzed by the enzyme.
  • Formerly EC and EC 1.14.13.n1.
PRIAM enzyme-specific profiles1.14.14.40
KEGG Ligand Database for Enzyme Nomenclature1.14.14.40
IUBMB Enzyme Nomenclature1.14.14.40
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.14.40
A0A068Q7V0, C7916_PRUMU;  Q9FLC8, C79A2_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-