ID 1.14.14.50 DE tabersonine 3-oxygenase. AN CYP71D1V2. AN T3O. CA (1) 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = CA (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + CA H2O + oxidized [NADPH--hemoprotein reductase]. CA (2) (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)- CA 1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized CA [NADPH--hemoprotein reductase]. CC -!- This cytochrome P450 enzyme acts on 16-methoxytabersonine, leading to CC biosynthesis of vindoline in the plant Catharanthus roseus CC (Madagascar periwinkle). CC -!- It can also act on tabersonine, resulting in the production of small CC amounts of vindorosine. CC -!- The products are unstable and, in the absence of EC 1.1.99.41 will CC convert into 3-epoxylated compounds. DR I1TEM1, T3O_CATRO ; //